Incidence of amyotrophic lateral sclerosis-associated genetic variants: a clinic-based study

ConclusionOver half of our ALS patients carried variants of ALS-related genes, most of which were variants of uncertain significance (VUS). Family history of ALS could work as strong evidence for carrying P/LP variants regarding ALS. There was no additionally suggestive effect of indicators including early onset, progression rate, cognitive decline, or cerebellar ataxia on the recommendation of genetic testing in clinical practice.
Source: Neurological Sciences - Category: Neurology Source Type: research