Investigating the correlation between small molecular inhibitor utilization, peripheral blood monocytes, and treatment outcomes in Rosai Dorfman disease

This study is the largest analysis of Rosai Dorfman disease, that we are aware of, from a single inst itution. In this cohort, the utilization of small molecule inhibitors corresponded to a greater increase in partial responses than conventional therapies, although the opposite effect has been observed in complete responses. This finding can be attributed to the recent introduction of targeted agent s and shorter follow-up. We anticipate higher complete response rates with the use of small molecule in ongoing analyses over a longer follow-up period. The recognition of relative monocyte elevation prior to disease progression is an intriguing and to our knowledge, novel finding in the field of R osai Dorfman disease. Future studies aimed at elucidating the implications of this trend are in progress.
Source: Annals of Hematology - Category: Hematology Source Type: research