Itpa polymorphisms and the incidence of toxicities in children with acute lymphoblastic leukemia

Conclusions: HomITPA had a higher incidence of transaminitis and required a significantly larger dose reduction of 6-MP than wildtypeITPA. Further study is warranted to elucidate the effects ofITPA polymorphisms on toxicity in patients with ALL treated with 6-MP.

Source: Mediterranean Journal of Hematology and Infectious Diseases - February 28, 2023 Category: Hematology Authors: Patpetra Svasdisant, Waraporn Glomglao, Preeyanun Siraprapapat, Wiyakan Inthararujikul , Kalaya Tachavanich, Chetsada Boonthimat, Sakkarin Ardsiri, Kochpinchon Chansing, Suwimon Sriprach , Sasima Tongsai , Phakatip Sinlapamongkolkul , Kleebsabai Sanpa Source Type: research