Her6 and Prox1a are novel regulators of photoreceptor regeneration in the zebrafish retina

In this study, we tested whether factors in volved in dedifferentiation ofDrosophila CNS are implicated in the regenerative response in the zebrafish retina. We found thathairy-related 6 (her6) negatively regulates of PR production by regulating the rate of cell divisions in the MG-derived progenitors.prospero homeobox 1a (prox1a) is expressed in differentiated PRs and may promote PR differentiation through phase separation. Interestingly, upon Her6 downregulation, Prox1a is precociously upregulated in the PRs, to promote PR differentiation; conversely, loss of Prox1a also induces a downregulation of Her6. Together, we identified two novel candidates of PR regeneration that cross regulate each other; these may be exploited to promote human retinal regeneration and vision recovery.
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research