The co-regulation of the gut microbiome and host genes might play essential roles in metformin gastrointestinal intolerance

In conclusion, this study suggests that metformin intolerance may be attributed to a decrease in anti-inflammatory-related flora and genes, and also alterations in PBAs accumulation-related flora. These findings open up possibilities for future research targeting gut flora and host genes to prevent metformin intolerance.PMID:37871735 | DOI:10.1016/j.taap.2023.116732

Source: Toxicology and Applied Pharmacology - October 23, 2023 Category: Toxicology Authors: Huixiang Zhang Jiao Lai Lihuan Zhang Wei Zhang Xun Liu Qilin Gong Hongxi Tian Mingzhi Yang Tao Yang Rui Zhao Dongqing Li Hehua Huang Ya Zhao Shan Yan Ming Yu Yanbin Xiyang Lanlan Shi Lirong Yang Limei Wang Weiwen Chen Xue Cao Source Type: research