High pyroptosis activity in pancreatic adenocarcinoma: poor prognosis and oxaliplatin resistance

ConclusionsIn this study, we found that higher pyroptosis activity is associated with worse prognosis and oxaliplatin resistance of PDAC patients. In addition, as a core effector of pyroptosis, GSDMC promoted proliferation and oxaliplatin resistance of pancreatic cancer cells, which will provide new therapeutic target for PDAC patients.
Source: Apoptosis - Category: Molecular Biology Source Type: research