Circulating metabolites and risk of incident dementia: A  prospective cohort study

Our results highlighted that the circulating levels of L-LDL-C% and L-LDL-CE% were associated with lower risk of all-cause dementia and AD, lower risk of cognitive deficits, and greater brain cortical and hippocampal brain volume, but not with VD. Circulating concentrations of S-HDL-CE were associated with lower risk of all-cause dementia and VD, but not with AD. These metabolites may play a role in the advancement of future intervention trials of dementia. AbstractIdentifying circulating metabolites associated with dementia, cognition, and brain volume may improve the understanding of dementia pathogenesis and provide novel insights for preventive and therapeutic interventions. This cohort study included a total of 87  885 participants (median follow-up of 9.1 years, 54% female) without dementia at baseline from the UK Biobank. A total of 249 plasma metabolites were measured using nuclear magnetic resonance spectroscopy at baseline. Cox proportional regression was used to examine the associations of each meta bolite with incident dementia (cases = 1134), Alzheimer's disease (AD; cases = 488), and vascular dementia (VD; cases = 257) during follow-up. Dementia-associated metabolites were further analyzed for association with cognitive deficits (N = 87 885) and brain volume (N = 7756) using logistic regression and linear regression. We identified 26 metabolites associated with incident dementia, of which 6 were associated with incident AD and 5 were as...
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: ORIGINAL ARTICLE Source Type: research