Current ART, determinants for virologic failure and implications for HIV drug resistance: an umbrella review

CONCLUSION: The resistance to HIV drugs and instances of determinants for virologic failure have a profound impact on the life quality of those infected with HIV. Primary contributors to this scenario include insufficient adherence to treatment, decreased CD4 T-cell count, elevated viral levels, and certain treatment regimens. Implementing appropriate interventions could address these issues. Sub-Saharan Africa exhibits elevated rates of determinants for virologic failure, attributed to the delay in HIV testing and diagnosis, and late initiation of antiretroviral therapy (ART). It is essential to undertake further research aimed at enhancing the detection of resistance in HIV patients and mitigating viral failure by addressing these underlying causes.PMID:37884997 | PMC:PMC10604802 | DOI:10.1186/s12981-023-00572-6
Source: AIDS Research and Therapy - Category: Infectious Diseases Authors: Source Type: research