Immunogenicity and Safety of 13-Valent Pneumococcal Conjugate Vaccine in HIV-Infected Adults Previously Vaccinated With Pneumococcal Polysaccharide Vaccine

Conclusions. Vaccination with PCV13 induces anticapsular immunoglobulin G and opsonophagocytic antibody responses in HIV-infected adults with prior PPSV23 vaccination and CD4 cell counts ≥200 cells/mm3. The observations support the use of PCV13 in this population.
Clinical Trials Registration. NCT00963235.

Source: The Journal of Infectious Diseases - June 11, 2015 Category: Infectious Diseases Authors: Glesby, M. J., Watson, W., Brinson, C., Greenberg, R. N., Lalezari, J. P., Skiest, D., Sundaraiyer, V., Natuk, R., Gurtman, A., Scott, D. A., Emini, E. A., Gruber, W. C., Schmoele-Thoma, B. Tags: HIV/AIDS Source Type: research