A Comprehensive Investigation into the Association Between Mthfr C677t, A1298c, and Ace I/D Variants and Risk of Migraine: an Updated Meta-Analysis of Genetic Association Studies with Trial Sequential Analysis and Meta-Regression

AbstractMany homeostatic genes are thought to play a role in the susceptibility to migraine, making it a highly complex neurovascular disease. In this meta-analysis, our primary objective was to evaluate whether or notMTHFR variants (such as C677T and A1289C) andACE I/D were associated with an increased risk of migraine. Using a PRISMA-based systematic literature-review guideline, internet sources such as PubMed and Google Scholar were searched to identify the genes of interest and migraine risk. To pool the data, odds ratios with 95% confidence intervals were calculated utilizing different genetic models. Cochran ’sQ Test andI2 statistics were used to access heterogeneity, while Begg ’s and Egger’s tests were used to identify publication bias. All tests were two-sided, and ap-value of  <  0.05 was regarded as statistically significant. The present meta-analysis observed that the C677T variant is significantly associated with the increased risk of migraine (allele model: OR:1.19, CI [1.07–1.33],I2 = 78%) and its clinical subtype i.e., MA (allele model: OR: 1.26, CI [1.09–1.45],I2 = 80%) in the overall population. Concerning theACE- I/D, it significantly increased the risk of overall migraine and both clinical subtypes after utilizing the dominant genetic models (OR: 1.14, CI [1.01 –1.29],I2%  = 32). Concerning theMTHFR A1289C, only the codominant model (HR vs HT) and recessive model significantly increased the risk of overall migraine. Therefore...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research