Viral infections and incidence of reactivations in chronic myeloid leukemia patients

Oncology. 2023 Oct 17. doi: 10.1159/000534266. Online ahead of print.ABSTRACTViral infections remain a significant problem for patients with chronic myeloid leukemia (CML) who undergo stem cell transplants (SCT). These infections often result from the reactivation of latent viruses. However, our understanding of the risk of viral reactivation in CML patients who have not undergone SCT is limited, and there is a scarcity of data on this topic. Tyrosine kinase inhibitors (TKI) have revolutionized the treatment of CML, as it is highly successful and has transformed the prognosis of patients with CML. However, TKI may be associated with an increased risk of infections. We have performed a literature search for publications related to viral infections and their reactivations in patients with chronic myeloid leukemia using PubMed, Scopus, and Google Scholar for the period 2001-2022. The population consisted of patients over 18 years old with a diagnosis of CML and no history of bone marrow transplantation. In an analysis of 41 patients, with 25 males and 16 females, M: F ratio of 1.56:1, and a median age of 50. Age ranged from 22 to 79 years. Most patients with reported viral infections or reactivations were in the chronic phase of CML, with 22 patients (76%) in the chronic phase, 6 patients (21%) in the accelerated phase, and one patient (3%) in the blast phase. Most cases with reported outcomes responded to treatment for CML; only one had refractory disease, and 8 cases (32%) had...
Source: Oncology - Category: Cancer & Oncology Authors: Source Type: research