The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats

CONCLUSIONS: Rat liver cytochrome P450 functions deteriorate with age, which may impair drug metabolism. The TPH2 knockout, which deprives brain serotonin, affects cytochrome P450 expression and activity differently in mature and senescent male rats.PMID:37848703 | DOI:10.1007/s43440-023-00540-x

Source: Pharmacological Reports - October 17, 2023 Category: Drugs & Pharmacology Authors: Anna Haduch Ewa Bromek Wojciech Kuban Agnieszka Basi ńska-Ziobroń Przemys ław J Danek Natalia Alenina Michael Bader W ładysława A Daniel Source Type: research