The gene expression and proteomic profiling of Acanthamoeba isolates

CONCLUSION: The gene expression data suggests that lysophospholipase, phospholipase, S8/S53 peptidase, carboxylesterase, and mannose-binding protein (MBP) could play a role in the contact-dependent and independent mechanisms of Acanthamoeba pathogenesis. In addition, the proteomic profiling of the 3 isolates revealed differential protein expression crucial for parasite growth, survival, and virulence. Our results provide baseline data for selecting possible pathogenic targets that could be utilized for designing knockout experiments in the future.PMID:37820893 | DOI:10.1016/j.exppara.2023.108630
Source: Experimental Parasitology - Category: Parasitology Authors: Source Type: research