Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone mice

CONCLUSION: TSEC does not aggravate a mouse model of lupus, when given in doses that protect against postmenopausal lupus-associated bone loss. This indicates that further investigations into TSEC as a treatment for osteoporosis or vasomotor symptoms in postmenopausal women with SLE are warranted.PMID:37722827 | DOI:10.1080/03009742.2023.2251753

Source: Scandinavian Journal of Rheumatology - September 18, 2023 Category: Rheumatology Authors: C Drevinge J M Scheffler J Nordqvist C Engdahl H Carlsten U Islander Source Type: research