The cancer-associated glycan polysialic acid is dysregulated in systemic sclerosis and is associated with fibrosis

CONCLUSION: Polysia is more abundant in the skin and sera from patients with SSc and correlates with the degree of skin fibrosis. The aberrant expression of polySia highlights its potential use as a biomarker in patients with progressive forms of SSc. Dysregulated polySia levels in SSc further emphasizes the cancer-like phenotype present in SSc, which may promote fibrosis and immune dysregulation.PMID:37742510 | DOI:10.1016/j.jaut.2023.103110

Source: Journal of Autoimmunity - September 24, 2023 Category: Allergy & Immunology Authors: Lamia Khan Tahlia Derksen Desiree Redmond Jan Storek Caylib Durand Robert Gniadecki Benjamin Korman Jan Willem Cohen Tervaert Ana D'Aubeterre Mohammed S Osman Lisa M Willis Source Type: research