Molecules, Vol. 28, Pages 6732: Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives
Molecules, Vol. 28, Pages 6732: Antioxidant and Hypolipidemic Activities of Cinnamic Acid Derivatives
Molecules doi: 10.3390/molecules28186732
Authors:
Christina Nouni
Panagiotis Theodosis-Nobelos
Eleni A. Rekka
Oxidative stress and hyperlipidemia are important factors for the initiation and progression of various cell degenerative pathological conditions, including cardiovascular and neurological diseases. A series of cinnamic acid-derived acids, such as ferulic acid, sinapic acid, 3,4-dimethoxycinnamic acid, p-coumaric acid, and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid, were esterified or amidated with various moieties, bearing different biological activities, and evaluated. The antioxidant and radical scavenging abilities of the compounds via inhibition of rat hepatic microsomal membrane lipid peroxidation, as well as their interaction with the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH), were assessed. Further, their hypolipidemic activity in vivo was tested. The majority of the obtained compounds demonstrated considerable radical scavenging and antioxidant action, with a parallel decrease in Triton-induced hyperlipidemia in rats. The (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid derivative with morpholine and 4-methylpiperidine (compounds 4 and 13, respectively) significantly decreased triglycerides and total cholesterol in the plasma of hyperlipidemic rats, with an antioxidant capacity similar to that of the antioxidant Trolox. T...
Source: Molecules - Category: Chemistry Authors: Christina Nouni Panagiotis Theodosis-Nobelos Eleni A. Rekka Tags: Article Source Type: research
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