Male kidney-specific BMAL1 knockout mice are protected from Potassium-deficient, high salt diet-induced blood pressure increases

Am J Physiol Renal Physiol. 2023 Sep 14. doi: 10.1152/ajprenal.00126.2023. Online ahead of print.ABSTRACTThe circadian clock protein BMAL1 is a transcription factor that impacts kidney function, including blood pressure (BP) control. Previously, we showed that male, but not female, kidney-specific cadherin Cre positive BMAL1 knockout mice (KS-BMAL1 KO) exhibit lower BP compared to littermate controls. The goal of this study was to determine the BP phenotype and immune response in male KS-BMAL1 KO in response to a low potassium, high salt diet (LKHS). BP, renal inflammatory markers and immune cells were measured in male mice following LKHS diet. Male KS-BMAL1 KO had lower BP following a LKHS compared to control mice, yet their circadian rhythm in pressure remained unchanged. Additionally, KS-BMAL1 KO exhibited lower levels of renal pro-inflammatory cytokines and immune cells following LKHS diet compared to control mice. KS-BMAL1 KO were protected from salt-sensitive hypertension observed in control mice and display an attenuated immune response following an LKHS diet. These data suggest that BMAL1 plays a role in driving the BP increase and the pro-inflammatory environment that occurs in response to an LKHS diet.PMID:37706232 | DOI:10.1152/ajprenal.00126.2023
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Source Type: research