Human PLCG2 Haploinsufficiency Results in a Novel NK Cell Immunodeficiency

CONCLUSIONS: PLCG2 haploinsufficiency represents a distinct syndrome from previous variants characterized by NK cell immunodeficiency with herpes virus susceptibility, expanding the spectrum of PLCG2-related disease.PMID:37714437 | DOI:10.1016/j.jaci.2023.09.002

Source: Herpes - September 15, 2023 Category: Infectious Diseases Authors: Joshua B Alinger Emily M Mace Justin R Porter Annelise Y Mah-Som Allyssa L Daugherty Stephanie Li Allison A Throm Jeanette T Pingel Nermina Saucier Albert Yao Ivan K Chinn James R Lupski Mohammad Ehlayel Michael Keller Greg R Bowman Megan A Cooper Jordan Source Type: research