Induced Pluripotent Stem Cells in Disease Biology and the Evidence for Their In Vitro Utility

Annu Rev Genet. 2023 Sep 14. doi: 10.1146/annurev-genet-022123-090319. Online ahead of print.ABSTRACTMany human phenotypes are impossible to recapitulate in model organisms or immortalized human cell lines. Induced pluripotent stem cells (iPSCs) offer a way to study disease mechanisms in a variety of differentiated cell types while circumventing ethical and practical issues associated with finite tissue sources and postmortem states. Here, we discuss the broad utility of iPSCs in genetic medicine and describe how they are being used to study musculoskeletal, pulmonary, neurologic, and cardiac phenotypes. We summarize the particular challenges presented by each organ system and describe how iPSC models are being used to address them. Finally, we discuss emerging iPSC-derived organoid models and the potential value that they can bring to studies of human disease. Expected final online publication date for the Annual Review of Genetics, Volume 57 is November 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.PMID:37708421 | DOI:10.1146/annurev-genet-022123-090319
Source: Annual Review of Genetics - Category: Genetics & Stem Cells Authors: Source Type: research