Targeted delivery of miR125a-5p and human Factor VIII attenuates molecular mediators of hemophilic arthropathy

Hemophilic arthropathy (HA) due to repeated bleeding into the joint cavity is a major cause of morbidity in patients with hemophilia. The molecular mechanisms contributing to this condition are not well characterized. MicroRNAs (miRs) are known to modulate the phenotype of multiple joint diseases such as osteoarthritis (OA) and rheumatoid arthritis (RA). Since miR125a is known to modulate disease progression in OA and RA, we performed a targeted screen of miR125a-5p and its target genes in a murine model of chronic HA.

Source: Thrombosis Research - September 15, 2023 Category: Hematology Authors: Mohankumar B. Senthilkumar, Pratiksha Sarangi, Sonal Amit, Senthilnathan Senguttuvan, Narendra Kumar, Giridhara R. Jayandharan Source Type: research