The Association Between Blood Pressure Control and Global Longitudinal Strain in Patients With HER2-Positive Breast Cancer on Trastuzumab-Based Regimens

Hypertension is an established risk factor for cancer therapy –related cardiac dysfunction and is independently associated with heart failure in patients with breast cancer (BC).1-3 Increased afterload and compensatory myocardial remodeling due to hypertension, including increased wall thickness and decreased chamber size, are associated with worsening myoca rdial mechanics, as evidenced by a decrease in global longitudinal strain (GLS).3,4 A community-based study among adults aged ≥50 years demonstrated that ambulatory blood pressure (BP) control was associated with impaired GLS.
Source: Journal of the American Society of Echocardiography - Category: Cardiology Authors: Tags: Brief Research Communication Source Type: research