Delayed esophageal anastomotic complication and ramucirumab therapy: A case report

In conclusion, this is the only known report of delayed esophageal anastomotic complication associated with ramuciru mab. VEGF inhibitor therapies such as bevacizumab have been associated with late (greater than 3 months postoperative) colorectal anastomotic complications including fistulas and leaks. Risk factors that have been associated are perioperative radiotherapy and history of early postoperative leak. The se findings raise concern whether VEGF inhibitor therapy should be used in post-esophagectomy patients with recurrence if these rare but catastrophic events are likely to be terminal.

Source: Thoracic Cancer - September 5, 2023 Category: Cancer & Oncology Authors: Robert H. Roth, Madison J. Malfitano, Matthew Reilley, Linda W. Martin Tags: CASE REPORT Source Type: research