Pharmacologic hyperreactivity of kappa opioid receptors in periaqueductal gray matter during alcohol withdrawal syndrome in rats

CONCLUSIONS: In general, stimulation/blockade of KOR in A-withdrawal animals exert higher responses compared to A-naïve ones. SAL-A produced anxiety-like behaviors and increased alcohol consumption/preference, especially/solely in the alcohol-withdrawal condition, while PF-04455242 augmented exploration with no effects on alcohol intake/preference. Our findings suggest a possible pharmacologic hyperreactivity of the KOR in PAG during alcohol withdrawal.PMID:37658980 | DOI:10.1007/s43440-023-00522-z

Source: Pharmacological Reports - September 2, 2023 Category: Drugs & Pharmacology Authors: Priscila V ázquez-León Abraham Miranda-P áez Hugo S ánchez-Castillo Bruno A Marichal-Cancino Source Type: research