Metformin has anti-inflammatory effects and induces immunometabolic reprogramming in hidradenitis suppurativa via multiple mechanisms

CONCLUSIONS: Our study provides insight into the mechanisms of action of metformin in HS. The anti-inflammatory effects of metformin support its use as a therapeutic agent in HS, while its effects on immunometabolism suggest that targeting metabolism is a promising therapeutic option in inflammatory diseases, including HS.PMID:37648653 | DOI:10.1093/bjd/ljad305

Source: The British Journal of Dermatology - August 30, 2023 Category: Dermatology Authors: Andreea Petrasca Roisin Hambly Niamh Kearney Conor M Smith Emily K Pender Julie Mac Mahon Aoife M O'Rourke Mohamed Ismaiel Patrick A Boland Jose P Almeida Czara Kennedy Alexandra Zaborowski Siun Murphy Desmond Winter Brian Kirby Jean M Fletcher Source Type: research