Recommandations pour la pratique clinique Nice/Saint-Paul-de-Vence 2022 –2023 : Prise en charge du cancer de l'endomètre métastatique et/ou en rechute
Bull Cancer. 2023 Jun;110(6S):6S34-6S43. doi: 10.1016/S0007-4551(23)00332-6.ABSTRACTRecommendations for clinical practice Nice/Saint-Paul-de-Vence 2022-2023 : Management of advanced/relapsing endometrial cancer Since the first recommendations in 2020 concerning metastatic and/or relapsed endometrial cancer, new treatment options have shown a benefit on patients' life expectancy, justifying their update. In first line, the choice will be made between chemotherapy with carboplatin/paclitaxel or hormone therapy with progestin, depending on tumor characteristics (histological type, grade, expression of hormone receptors, rate of progression). In case of a dMMR tumors, the use of immunotherapy within the framework of a therapeutic trial is an option. Beyond first-line chemotherapy, current standard treatment consists of the combination of pembrolizumab and lenvatinib, regardless of MMR status. Close clinical and biological monitoring is however necessary given the potential toxicity. Chemotherapy retains its place either as monotherapy (paclitaxel or doxorubicin) in the event of failure or contraindication to pembrolizumab-lenvatinib, or in combination with carboplatin in the event of a long free interval and pMMR tumor. The numerous ongoing clinical trials evaluating new therapeutic targets or strategies adapted to molecular or histological types should allow further improvements the prognosis of patients with metastatic endometrial cancer.PMID:37573037 | DOI:10.1016/S0007-4551(2...
Source: Bulletin du Cancer - Category: Cancer & Oncology Authors: J érôme Alexandre Marie-Aude Le Fr ère-Belda Antoine Angelergues Gwena ël Ferron Isabelle Treilleux Anne-Lise Gaillard Jean-S ébastien Frenel Beno ît You Etienne Rouleau Alain Lortholary Isabelle Ray-Coquard Florence Joly Pour le groupe GINECO Source Type: research