Neutrophils for Revascularization Require Activation of CCR6 and CCL20 by TNF α

CONCLUSIONS: We demonstrate that site-specific activation of the CCL20-CCR6 axis via TNFα recruits proangiogenic VEGFA-expressing neutrophils to sites of ischemic injury for initiation of muscle tissue revascularization. The findings provide an attractive option for tissue revascularization, particularly under diabetic conditions.PMID:37641931 | DOI:10.1161/CIRCRESAHA.123.323071

Source: Circulation Research - August 29, 2023 Category: Cardiology Authors: Holger L örchner Laia Ca ñes Esteve Maria Elisa G óes Roxanne Harzenetter Nathalie Brachmann Praveen Gajawada Stefan G ünther Nicolas Doll Jochen P öling Thomas Braun Source Type: research