Development of a simplified human embryonic stem cell-based retinal pre-organoid model for toxicity evaluations of common pollutants

CONCLUSIONS: In this study we established a retinal pre-organoid model suitable for evaluating multiple pollutants' effects, and pointed out the potential retinal toxicity of flame retardants, among other pollutants. Nevertheless, the potential mechanisms of toxicity and the effects on cell detachment are still unclear and deserve further exploration. Additionally, this model holds promise for screening interventions aimed at mitigating the detrimental effects of these pollutants.PMID:37602871 | DOI:10.1080/15569527.2023.2249988

Source: Cutaneous and Ocular Toxicology - August 21, 2023 Category: Toxicology Authors: Yue Wang Nuoya Yin Renjun Yang Miaomiao Zhao Shichang Li Shuxian Zhang Yanyi Zhao Francesco Faiola Source Type: research