Dietary fat differentially modulates the response of bone marrow-derived macrophages to TLR4 and NOD2 agonists

In this study, we subjected WT mice to a control diet or to HFDs comprised of various ratios of unsaturated to saturated fats and determined the macrophage response to TLR4 and NOD2 agonists. A HFD with equal ratios of saturated and unsaturated fats enhanced subsequent responsiveness of macrophages to LPS but not to MDP. However, a high-unsaturated fat diet (HUFD) or a high-saturated fat diet (HSFD) both decreased the responsiveness to NOD2 agonists compared to that observed in control diet (CD) fed mice. These data suggest that dietary fatty acid composition can influence the subsequent macrophage responsiveness to bacterial products.PMID:37545346 | DOI:10.1177/17534259231193926

Source: Innate Immunity - August 7, 2023 Category: Allergy & Immunology Authors: Michael G Shehat Madelyn H Miller Ashley N Calder Timothy A Gilbertson Justine T Tigno-Aranjuez Source Type: research