Fantoms

Two-year outcomes following a randomised platelet-transfusion trial in preterm infants It is great to see the 2 year outcomes of the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion-2/Management of Thrombocytopenia in Special Subgroup) study in the journal. This randomised-controlled trial examined the outcomes of 660 preterm infants<34 weeks’ gestation with severe thrombocytopenia who were randomised to receive platelet transfusions if their platelet count fell below 50x109 /L (high threshold, liberal transfusion) or below 25x109 /L (low threshold, restrictive transfusion. Transfusion at a count below 50 was associated with a higher risk of the primary composite outcome of death or a new episode of major bleeding, suggesting that rather than being beneficial and protecting babies from haemorrhagic complications, platelet transfusions given to thrombocytopenic preterm infants may be harmful. Carmel Maria Moore and colleagues now report the outcomes at 2 years. The pre-specified composite outcome of death or neurodevelopmental impairment (developmental delay, cerebral palsy, seizure...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - Category: Perinatology & Neonatology Authors: Tags: Highlights from this issue Source Type: research