A pilot phase Ib study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wild-type glioblastoma

CONCLUSIONS: Concurrent tadalafil is well tolerated during chemoradiotherapy for GBM. Tadalafil is associated with a reduction of peripheral MDSCs after chemoradiotherapy and increased CD8 T-cell proliferation and activation.PMID:37554225 | PMC:PMC10406429 | DOI:10.1093/noajnl/vdad088

Source: Cancer Control - August 9, 2023 Category: Cancer & Oncology Authors: Subhajit Ghosh Tanner M Johanns Milan G Chheda Eric Liu Omar Butt Christopher Abraham Shahed Badiyan Yi Huang David DeNardo Albert H Kim Dennis Hallahan Dinesh Thotala Jiayi Huang Source Type: research