Prognostic impact of molecular profiles and molecular signatures in clear cell ovarian cancer

Ovarian Clear Cell Carcinomas (OCCC) account for 5-25% of all Epithelial Ovarian Cancer (EOC). It represents distinct molecular, clinical, and pathological characteristics compared with other EOC subtypes [1 –3]. Next Generation Sequencing (NGS) studies have demonstrated that OCCC comprise several molecular heterogeneous subtypes [4,5]. Still, all OCCC patients are treated with primary surgery followed by adjuvant platin/taxane-based chemotherapy despite low response rates and thus, a poor prognosis o f patients diagnosed in advanced stages [1,2].

Source: Cancer Genetics and Cytogenetics - August 3, 2023 Category: Genetics & Stem Cells Authors: Tine Henrichsen Schnack, Douglas-V.N.P. Oliveira, Anne Pernille Christiansen, Claus H øgdall, Estrid Høgdall Source Type: research