The Use of Tau PET to Stage Alzheimer Disease According to the Braak Staging Framework

Conclusion: Refinements in this staging system are necessary to incorporate atypical variants and Braak-nonconformant cases. Further studies are needed to understand the possible applications of PET-based Braak staging to clinical practice and research. Furthermore, there is a need for standardization in the topographic definitions of Braak stage regions of interest to guarantee reproducibility and methodologic homogeneity across studies.

Source: Journal of Nuclear Medicine - August 1, 2023 Category: Nuclear Medicine Authors: Macedo, A. C., Tissot, C., Therriault, J., Servaes, S., Wang, Y.-T., Fernandez-Arias, J., Rahmouni, N., Lussier, F. Z., Vermeiren, M., Bezgin, G., Vitali, P., Ng, K. P., Zimmer, E. R., Guiot, M.-C., Pascoal, T. A., Gauthier, S., Rosa-Neto, P. Tags: State of the Art Source Type: research