Cognitive Effects of Lurasidone and Cariprazine: A Mini Systematic Review

CONCLUSION: The cognitive effect of lurasidone could be explained by its potent antagonism at the 5- HT7 receptors combined with partial agonism at 5-HT1A receptors. The pro-cognitive effect of cariprazine is probably explained by its very high affinity for D3 receptors. Head-to-head studies com- paring lurasidone and cariprazine are needed to establish the "first-choice" treatment for cognitive dys- function associated with schizophrenia.PMID:37519001 | DOI:10.2174/1570159X21666230727140843

Source: Current Neuropharmacology - July 31, 2023 Category: Drugs & Pharmacology Authors: Miriam Olivola Nicola Bassetti Serena Parente Vincenzo Arienti Serena Chiara Civardi Pietro Alessandro Topa Natascia Brondino Source Type: research