Diphtheria toxin ‐derived, anti‐PD‐1 immunotoxin, a potent and practical tool to selectively deplete PD‐1+ cells

ConclusionWith its remarkable selective and potent cytotoxicity towards PD-1+ cells, coupled with its high production yield, PD-1 DIT emerges as a powerful biotechnological tool for elucidating the physiological roles of PD-1+ cells. Furthermore, the potential of PD-1 DIT to be developed into a novel therapeutic agent becomes evident.This article is protected by copyright. All rights reserved.

Source: Protein Science - July 30, 2023 Category: Biochemistry Authors: Tianxiao Zhang, Shuyun Dong, Yujia Zhai, Lauren Naatz, Zemin Zhou, Mingnan Chen Tags: RESEARCH ARTICLE Source Type: research