Implementation of DNA methylation array profiling in pediatric central nervous system tumors - the AIM BRAIN Project: an Australian and New Zealand Children ’s Haematology and Oncology (ANZCHOG) Group study.

DNA methylation array profiling for classifying pediatric central nervous system (CNS) tumors is a valuable adjunct to histopathology. However, unbiased prospective and inter-laboratory validation studies have been lacking. The AIM BRAIN (AB) diagnostic trial involving 11 pediatric cancer centers in Australia and New Zealand was designed to test the feasibility of routine clinical testing and ran in parallel with the Molecular Neuropathology 2.0 (MNP2.0) study at Deutsches Krebsforschungszentrum (DKFZ) (German Cancer Centre Heidelberg, Germany).

Source: Journal of Molecular Diagnostics - July 28, 2023 Category: Pathology Authors: Christine L. White, Kathryn M. Kinross, Molly K. Buntine, Elnaz Rasouli, Robyn Strong, Janelle M. Jones, Jason E. Cain, Dominik Sturm, Felix Sahm, David T.W. Jones, Stefan M. Pfister, Thomas Robertson, Colleen D ’Arcy, Michael L. Rodriguez, Jason M. Dyk Tags: Regular Article Source Type: research