Evaluating the oncological safety of neoadjuvant chemotherapy in locally advanced colon carcinoma: a systematic review and meta-analysis of randomised clinical trials and propensity-matched studies

ConclusionThis study highlights the oncological safety of NAC for patients being treated with curative intent for LACC using RCT and propensity-matched studies only. These results refute current management guidelines which do not advocate for NAC to improve surgical and oncological outcomes in patients with LACC.Trial registrationInternational Prospective Register of Systematic Review (PROSPERO) registration: CRD4202341723.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research