Human anti-N1 monoclonal antibodies elicited by pandemic H1N1 virus infection broadly inhibit HxN1 viruses in  vitro and in vivo

Optimizing neuraminidase antigenicity is essential for improving influenza vaccines. Hansen et  al. isolated human monoclonal antibodies with broad enzyme inhibition activity against human, avian, and swine N1 neuraminidase that provided robust protection in vivo. Cryo-EM revealed highly conserved sites on the lateral face of neuraminidase, distal to the active site.

Source: Immunity - July 27, 2023 Category: Allergy & Immunology Authors: Lena Hansen, Meagan McMahon, Hannah L. Turner, Xueyong Zhu, Jackson S. Turner, Gabriel Ozorowski, Daniel Stadlbauer, Juha Vahokoski, Aaron J. Schmitz, Amena A. Rizk, Wafaa B. Alsoussi, Shirin Strohmeier, Wenli Yu, Jos é Alberto Choreño-Parra, Luis Jimé Tags: Article Source Type: research