Constitutional MLH1 Methylation Is a Major Contributor to Mismatch Repair-Deficient, MLH1-Methylated Colorectal Cancer in Patients Aged 55 Years and Younger

CONCLUSIONS: Although rare overall, a significant proportion of younger patients with MLH1-methylated CRC had underlying constitutional MLH1 methylation. Routine testing for this high-risk mechanism is warranted in patients aged ≤55 years for a timely and accurate molecular diagnosis that will significantly alter their clinical management while minimizing additional testing.PMID:37433431 | DOI:10.6004/jnccn.2023.7020

Source: Journal of the National Comprehensive Cancer Network : JNCCN - July 11, 2023 Category: Cancer & Oncology Authors: Megan P Hitchins Estela D ámaso Rocio Alvarez Lisa Zhou Yajing Hu Marcio A Diniz Marta Pineda Gabriel Capella Rachel Pearlman Heather Hampel Source Type: research