Significance of O6-methyl guanine methyltransferase promoter methylation in high grade glioma patients: optimal cutoff point, CpG locus, and genetic assay

ConclusionOur outcomes support the prognostic value ofMGMT promoter methylation in patients with high grade glioma. Sequencing of whole promoter CpG islands demonstrated that methylation of particular CpG sites might predict clinical outcomes more precisely.

Source: Journal of Neuro-Oncology - July 20, 2023 Category: Cancer & Oncology Source Type: research