Prognostic Value of hsa_circ_0007615 in Epithelial Ovarian Cancer and its Regulatory Effect on Tumor Progression

This study aimed to interrogate the functional and clinical significance of
hsa_circ_0007615 in epithelial ovarian cancer (EOC). GSE192410 was screened for
upregulated circRNAs in ovarian cancer. The expression levels of
hsa_circ_0007615 were evaluated in a patient cohort comprising 113 EOC tissues
and matched normal tissues. Subsequently, the prognostic value was confirmed by
the relevance of hsa_circ_0007615 with clinical parameters, Kaplan–Meier
analysis and Cox proportional risk model. Cell functional analyses were
performed in EOC cell lines using a cell proliferation kit, transwell and cell
death kit. Our data revealed that hsa_circ_0007615 was significantly upregulated
in EOC tissues and cell lines, compared with normal ones. Multivariate survival
analysis revealed that hsa_circ_0007615 emerged as an independent risk factor
for overall survival and recurrence of EOC patients. Knockdown of
hsa_circ_0007615 in EOC cells led to the blocking of cell proliferation,
migration and invasion, but an increase of cell death presenting as ferroptosis.
Tumor suppressive effects of hsa_circ_0007615 knockdown can be abolished by
miR-874-3p inhibition. TUBB3 was a targeting gene of miR-874-3p.
Hsa_circ_0007615 has the functional and clinical significance of EOC.
Mechanistically, hsa_circ_0007615 may contribute to EO...

Source: Hormone and Metabolic Research - July 17, 2023 Category: Endocrinology Authors: Wei, Wei Wang, Ning Lin, Lin Tags: Original Article: Endocrine Research Source Type: research