Re: Single-cell transcriptome analysis for characterizing primary Sca-1 positive, non-endothelial cardiac cells

Sca-1+ cells in adult hearts have been considered intrinsic stem cells that can differentiate into cardiomyocytes and repair a damaged heart [1]. However, recent research has challenged this idea by suggesting that cardiac sca-1+ cells are actually endothelial cells [2]. Despite this, other studies have indicated the existence of sca-1+ non-endothelial cells in adult hearts, specifically cardiac mesenchymal stem cells (C-MSCs), that promote angiogenesis through paracrine actions and offer therapeutic benefits [3].
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Tags: Letter to the editor Source Type: research