Western Diet Decreases Hepatic Drug Metabolism in Male LDLr < sup > -/- < /sup > ApoB < sup > 100/100 < /sup > Mice

In conclusion, the WD-induced steatosis in male LDLr-/-ApoB100/100 mice was associated with decreased CYP oxidation reactions but had no clear effects on conjugation reactions of glucuronidation, sulfonation, and cytosolic catechol O-methylation. Consequently, the WD may decrease the metabolic elimination of drugs compared to healthier low-fat diets.PMID:37034183 | PMC:PMC10081903 | DOI:10.1155/2023/5599789
Source: Journal of Nutrition and Metabolism - Category: Nutrition Authors: Source Type: research