Transitional Insight into the RNA-Based Oligonucleotides in Cancer Treatment

Appl Biochem Biotechnol. 2023 Jul 4. doi: 10.1007/s12010-023-04597-5. Online ahead of print.ABSTRACTConventional cancer therapies with chemodrugs suffer from various disadvantages, such as irreversible side effects on the skin, heart, liver, and nerves with even fatal consequences. RNA-based therapeutic is a novel technology which offers great potential as non-toxic, non-infectious, and well-tolerable platform. Herein, we introduce different RNA-based platforms with a special focus on siRNA, miRNA, and mRNA applications in cancer treatment in order to better understand the details of their therapeutic effects. Of note, the co-delivery of RNAs with other distinct RNA or drugs has provided safe, efficient, and novel treatment modalities for cancer treatment.PMID:37402038 | DOI:10.1007/s12010-023-04597-5
Source: Applied Biochemistry and Biotechnology - Category: Biochemistry Authors: Source Type: research