The Aging of the Enteric Nervous System

The enteric nervous system is the nervous system of the intestines, and likely an important part of the relationship between the gut microbiome and the brain. One of the more interesting parts of this review paper is the discussion regarding relationships between the gut microbiome and enteric nervous system. All too little is known in detail, even while it is possible to find reports of specific associations and points of communication between gut microbiome and nervous system. Given the attention to measuring and altering the balance of populations in the gut microbiome, one might hope that the advent of ways to sizeably and favorably adjust the gut microbiome will meaningfully improve late life health. The gut and the brain communicate via the nervous system, hormones, microbiota-mediated substances, and the immune system. These intricate interactions have led to the term "gut-brain axis". Unlike the brain-which is somewhat protected-the gut is exposed to a variety of factors throughout life and, consequently, might be either more vulnerable or better adapted to respond to these challenges. Alterations in gut function are common in the elder population and associated with many human pathologies, including neurodegenerative diseases. Different studies suggest that changes in the nervous system of the gut, the enteric nervous system (ENS), during aging may result in gastrointestinal dysfunction and initiate human pathologies of the brain via its interconnection with...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs