Reviewing the Role of TFEB Upregulation in Approaches Shown to Slow Aging

Most of the varied approaches shown to modestly slow the progression of aging appear to operate through a small number of common mechanisms, largely involving the cellular response to stress. Some of those mechanisms will turn out to be more influential than others, though little progress has been made towards assigning relative importance to the various layers of the exceedingly complex reactions to heat, cold, restriction of nutrients, and other forms of mild stress that can produce beneficial outcomes. The most compelling evidence to date suggests that improved autophagy is one of the more relevant portions of the cellular response to stress, a greater recycling of worn and damaged cell components leading to improved function over time. Here, researchers discuss TFEB, a regulator of autophagy, in the context of interventions shown to slow aging. In this context, it is worth noting that stress response enhancement of longevity appears to produce much larger effects in short-lived species than in long-lived species. In the two cases where one can compare fairly directly compare humans with mice, the practice of calorie restriction and loss of function mutations in growth hormone signaling, there is no evidence for a sizable increase in life span in our species. TFEB is a central regulator of the aging process and age-related diseases Extending lifespan or delaying aging has been shown to protect against degenerative diseases, and interventions that slo...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs