Dynamic Control of Contractile Force in Engineered Heart Tissue

Conclusion: EHT contractility can be regulated dynamically through feedback control of effective boundary stiffness. Significance: The capacity to alter the mechanical boundary conditions of an engineered tissue dynamically offers a new way to probe tissue mechanics. This could be used to mimic afterload changes that occur naturally in disease, or to improve mechanical techniques for EHT maturation.
Source: IEEE Transactions on Biomedical Engineering - Category: Biomedical Engineering Source Type: research