Humoral SARS-CoV-2 vaccine responses in patients with giant cell arteritis and polymyalgia rheumatica: decay after primary vaccination and effects of the booster

CONCLUSION: These results indicate that the decay of humoral immunity after primary vaccination is associated with prednisolone treatment, whereas the subsequent increase after booster vaccination, was not. Patients with low antibody concentrations following primary vaccination remained at an immunogenic disadvantage after a single booster vaccination. This longitudinal study in GCA/PMR patients stresses the importance of repeated booster vaccination for patients with poor responses to primary vaccination. This article is protected by copyright. All rights reserved.PMID:37332051 | DOI:10.1002/acr.25173

Source: Cell Research - June 18, 2023 Category: Cytology Authors: Yannick van Sleen Kornelis Sm van der Geest Anne-Marie Buisman Maria Sandovici Debbie van Baarle Elisabeth Brouwer Source Type: research