Blockade of glucagon increases muscle mass and alters fiber type composition in mice deficient in proglucagon ‐derived peptides

ConclusionsThese results show that hyperaminoacidemia induced by blockade of glucagon action in mice increases skeletal muscle weight and stimulates slow-to-fast transition in type  II fibers of skeletal muscle, mimicking the phenotype of a high-protein diet.

Source: Journal of Diabetes Investigation - June 10, 2023 Category: Endocrinology Authors: Shinji Ueno, Yusuke Seino, Shihomi Hidaka, Masashi Nakatani, Keisuke Hitachi, Naoya Murao, Yasuhiro Maeda, Haruki Fujisawa, Megumi Shibata, Takeshi Takayanagi, Katsumi Iizuka, Daisuke Yabe, Yoshihisa Sugimura, Kunihiro Tsuchida, Yoshitaka Ha Tags: Original Article Source Type: research