Weight loss improves inflammation by T helper 17 cells in an obese patient with psoriasis at high risk for cardiovascular events

In this study, we found an increase in Th17 cells in a patient with obesity, type 2 diabetes and psoriasis. Furthermore, weight loss with diet and exercise resulted in a decrease in Th17 cells and improvement of psoriasis. This case supports the hypothesis that obesity leads to an increase in Th1 7 cells and chronic inflammation of the skin and blood vessel walls, thereby promoting psoriasis and atherosclerosis.

Source: Journal of Diabetes Investigation - June 9, 2023 Category: Endocrinology Authors: Yoshiro Maezawa, Yusuke Endo, Satomi Kono, Tomohiro Ohno, Yuumi Nakamura, Naoya Teramoto, Ayano Yamaguchi, Kazuto Aono, Takuya Minamizuka, Hisaya Kato, Takahiro Ishikawa, Masaya Koshizaka, Minoru Takemoto, Toshinori Nakayama, Koutaro Yokote Tags: CASE REPORT Source Type: research