Lymphoma-Sink Effect in Marginal Zone Lymphoma Based on CXCR4-Targeted Molecular Imaging

ConclusionsInvestigating a lymphoma-sink effect in patients with hematological neoplasms, we observed no relevant associations between lymphoma burden and uptake in normal organs. Those observations may have therapeutic implications, e.g., for “cold” SDF1-pathway disrupting or “hot,” CXCR4-directed radiolabeled drugs, as with higher lymphoma load, normal organ uptake seems to remain stable.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research